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184 resources found
Brochures
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Defining resistance mechanisms of measurable residual disease (MRD) with single-cell multiomics
Empower Your Cell and Gene Therapy Development Programs with Sensitive and Precise Single-Cell Multiomics
Focusing single-cell whole genome sequencing and analysis resources on the cells that matter the most
Gene Edited Off-Target Events Identified Through Single-Cell Whole Genome Sequencing
ResolveDNA® scDNAseq Product Brochure
ResolveDNA® WGA Product Brochure
ResolveOME™ Product Brochure
ResolveSEQ LongRead Early Access Program
ResolveServices Brochure
The Next Generation Single-Cell Technology
Transform Your Hematology Research with Sensitive and Precise Single-Cell Multiomics
Publications
2021 AGBT: Accurate detection of small genomic variants, copy number alterations, and heteroplasmy in early human embryos.
2021 AGBT: Distinct resistance modalities to targeted kinase inhibition exposed by single-cell Primary Template-directed Amplification in acute myeloid leukemia and triple-negative breast cancer.
2021 AGBT: Improving the sensitivity of detection of low frequency somatic variants via Primary Template-directed Amplification of single cells.
2021 AGBT: Unifying genomics and transcriptomics in single cells to illuminate cancer...
2022 AGBT: Combined ResolveDNA® whole genome amplification with Twist Human Core Exome panel to generate high-quality human whole-exome data from single cells
2022 AGBT: Exploring microbial biodiversity through genome analysis using ResolveDNA Microbiome
2022 AGBT: Single-cell clarity and heterogeneity in copy number profiles in primary synovial & Ewing sarcoma with ResolveDNA™ genomic amplification
2022 AGBT: The ResolveOME™ platform: integrated whole genome and whole transcriptome profiling from a single cell to unlock drug resistance mechanisms
2022 ASHG: Co-delineating genomic and transcriptomic modes of resistance to MEK inhibition in individual triple negative breast cancer cells
2022 ASHG: Exploring drug resistance mechanisms in different drug resistance models of an AML cell line using ResolveOME™ combined genomics and transcriptomics chemistry
2022 ASHG: Extracellular protein monitoring in the ResolveOME™ genomic and transcriptomic dual workflow to uncover cancer pathology mechanisms in single cells
2022 ASHG: Going beyond the atlas – mapping the tumor landscape with complete genomic signatures
2022 ASHG: Single-cell identity and state coupled with genome-wide SNV and CNV in primary breast cancer with ResolveOME™ profiling
2022 ASHG: The BaseJumper™ research platform for single cell multiomic analysis & interactive visualization
2022 ASHG: Unbiased linkage of SNV to expression in single cells for regulatory variant discovery influencing cancer drug resistance
2022 ASM: Charting and deconvolution of microbial diversity by high-quality single-cell genomic reconstruction utilizing ResolveDNA Microbiome
2023 AACR: Single Day Workflow for High-Quality Whole Genome Analysis of Thousands of Single Cells with ResolveDNA
2023 AACR: Trimodal Molecular Analysis in Single Cells of a Primary Breast Cancer Cohort with ResolveOME Amplification
2023 AGBT: Integration of the ResolveOME™ multi-omics workflow with IDT xGen™ hybridization capture at single-cell resolution to obtain high quality exome data
2023 ASHG: Elucidation Of Tumor Clonal Diversity in An AML Drug Resistance Model Using A High Throughput Single Cell Genome Amplification Method
2023 ASHG: Multiomic Single Cell Analysis of Primary Pancreatic Ductal Adenocarcinoma Enhanced by Fixation
2023 ASHG: Quantitative characterization of on-target and off-target variation induced by CRISPR+Cas9 systems at the single-cell resolution
2023 ASHG: Unveiling Inter- and Intra-Tumor Heterogeneity in Ductal Carcinoma in Situ (DCIS) and Invasive Ductal Carcinoma (IDC) through Integration of Unified Single-Cell Copy Number and RNA Expression Data
2024 AACR: Inter- and intratumoral PIK3CA subclonal diversity in breast cancer contextualized by single-cell multiomics
2024 AGBT: Adaptation of MAS-Seq/PacBio and ONT long read technology to the ResolveOME™ multiomic workflow for single-cell transcript isoform and DNA amplicon interrogation
2024 AGBT: Broadening the input application of ResolveDNA genomic amplification to detection of SNV in circulating DNA
2024 AGBT: Enrichment of viable cells from patient samples with LeviCell technology as input into the ResolveOME single cell multiomic workflow
2024 AGBT: Exome, IcWGS-based copy number assessment, complete transcriptome & surface protein expression from the same individual cell with ResolveOME™
2025 AGBT: A high-plexity exome solution tailored for sensitive variant detection in single cells
2025 ASHG: BaseJumper® genome analysis workflows with custom DeepVariant showcase best performance in variant detection across classifications, chemistries and sample types
2025 ASHG: Novel single-cell whole genome amplification long-read workflow highlights complex variation mosaicism
A comprehensive view of somatic mosaicism by single-cell DNA analysis
A novel high-throughput single-cell DNA sequencing method reveals hidden genomic heterogeneity in the unicellular eukaryote Leishmania
A spinal and bulbar muscular atrophy (SBMA) disease-specific human embryonic stem cell (hESC) line, UMICHe002-A/UM197-1
Accurate Genomic Variant Detection in Single Cells with Primary Template-Directed Amplification
Analysis of DNA from brain tissue on stereo-EEG electrodes reveals mosaic epilepsy-related variants
Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability
Artificial intelligence-driven morphology-based enrichment of malignant cells from body fluid
Cell-type-informed genotyping of mosaic focal epilepsies reveals cell-autonomous and non-cell-autonomous disease-associated transcriptional programs
Cell-type-resolved mosaicism reveals clonal dynamics of the human forebrain
Comparative analysis of whole genome amplification kits for single cell genome analysis
Comprehensive benchmarking of somatic mutation detection by the SMaHT Network
Comprehensive profiling of L1 retrotransposons in mouse
Comprehensive single-cell genome analysis at nucleotide resolution using the PTA Analysis Toolbox
Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes
Defining heritability, plasticity, and transition dynamics of cellular phenotypes in somatic evolution
Delineating the copy-number substructure of metastatic tumors with CopyKit
Detecting somatic variants in purified brain DNA obtained from surgically implanted depth electrodes in epilepsy
Detection of Somatic Point Mutations Directly from Spatial Transcriptomics Enables in vivo Spatiotemporal Lineage Tracing
Development and extensive sequencing of a broadly-consented Genome in a Bottle matched tumor-normal pair
Developmental organization of sensory and sympathetic ganglia
Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy
Down syndrome (Trisomy 21) disease-specific human embryonic stem cell (hESC) lines, UMICHe003-A/UM152-1, UMICHe004-A/UM202-1, and UMICHe005-A/UM229-1
eBook: Cell and Gene Therapies
Enhanced SNP genotype recovery from low-template DNA using primary template-directed amplification and hybrid capture-based MPS
Extrachromosomal DNA Gives Cancer a New Evolutionary Pathway
Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma
Genome-Wide Disease Screening in Early Human Embryos with Primary Template-Directed Amplification
Genotype-to-Phenotype Mapping of Somatic Clonal Mosaicism via Single-Cell Co-Capture of DNA Mutations and mRNA Transcripts
High-fidelity, Large-scale Targeted Profiling of Microsatellites
High-Plexity, Single-Cell Exome Hybrid Capture of ResolveDNA® and ResolveOME™ Amplification Products
High-Plexity, Single-Cell Targeted Panel Hybrid Capture of ResolveDNA® and ResolveOME™ Amplification Products
High-Quality Nuclei Isolation from Postmortem Human Heart Muscle Tissues for Single-Cell Studies
High-resolution detection of copy number alterations in single cells with HiScanner
High-resolution single-cell mapping of clonal hematopoiesis and structural variation in aplastic anemia
Identification of a mosaic MTOR variant in purified neuronal DNA in a patient with focal cortical dysplasia using a novel depth electrode harvesting technique
Identification of multiple genomic alterations and prediction of neoantigens from circulating tumor cells at the single-cell level
Improved detection of colibactin-induced mutations by genotoxic E. coli in organoids and colorectal cancer
Integration of scHi-C and scRNA-seq data defines distinct 3D-regulated and biological-context dependent cell subpopulations
Large-scale single-cell phylogenetic mapping of clonal evolution in the human aging esophagus
Mapping single-cell diploid chromatin fiber architectures using DAF-seq
Molecular Effects of Indoor Tanning
Multidrug resistance transporter-1 dysfunction perturbs meiosis and Ca2+ homeostasis in oocytes
Neuronal somatic mutations are increased in multiple sclerosis lesions
Neurons accumulate disease-specific somatic genomic changes across tau pathologic states in Alzheimer's disease
Oncogene aberrations drive medulloblastoma progression, not initiation
Optimizing methods for virome analysis based on studies of a synthetic viral community
Pathogen dynamics and discovery of novel viruses and enzymes by deep nucleic acid sequencing of wastewater
Performance Evaluation of Whole-Genome Amplification Platforms for Clinical Next-Generation Sequencing with Minimal Nucleic Acid Input
Perinatal Elimination of Genetically Aberrant Neurons from Human Cerebral Cortex
Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity
Post-zygotic rescue of meiotic errors causes brain mosaicism and focal epilepsy
Precise exome analysis of blastocyst biopsy scale samples using primary template-directed amplification
Protocol for genome-wide analysis of somatic variants at single-cell resolution using primary template-directed DNA amplification
Quantitative and qualitative mutational impact of ionizing radiation on normal cells
Realtime morphological characterization and sorting of unlabeled viable cells using deep learning
Recurrent patterns of widespread neuronal genomic damage shared by major neurodegenerative disorders
scMicrobe PTA: near near complete genomes from single bacterial cells
Selective pressures of platinum compounds shape the evolution of therapy-related myeloid neoplasms
Seq2Karyotype (S2K): A Method for in-silico Karyotyping Using Single-Sample Whole-Genome Sequencing Data
Single cell whole genome and transcriptome sequencing links somatic mutations to cell identity and ancestry
Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements
Single-cell mapping of regulatory DNA-protein interactions
Single-Cell Sequencing Reveals Extensive Genetic Diversity Underlying Pediatric ALL Treatment Complexity
Single-cell somatic copy number variants in brain using different amplification methods and reference genomes
Single-cell transcriptomic and genomic changes in the aging human brain
Single-cell whole-genome sequencing reveals convergent evolution in Burkitt lymphoma
Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states
Somatic Genomic and Transcriptomic Changes in Single Ischemic Human Heart Cardiomyocytes
Somatic genomic changes in single Alzheimer’s disease neurons
Somatic mosaicism in ALS and FTD identifies focal mutations associated with widespread degeneration
Somatic Mosaicism in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Reveals Widespread Degeneration from Focal Mutations
Somatic Mosaicism in PIK3CA Variant Correlates With Stereoelectroencephalography-Derived Electrophysiology
Somatic mutation in human cerebellum illustrates neuron type-specific patterns of age-related mutation
Somatic mutations distinguish melanocyte subpopulations in human skin
Somatic mutations impose an entropic upper bound on human lifespan
The genomic landscape of relapsed infant and childhood KMT2A-rearranged acute leukemia
The Somatic Mosaicism across Human Tissues Network
Transient Differentiation-State Plasticity Occurs during Acute Lymphoblastic Leukemia Initiation
Ultra-low biomass sequencing workflow (LBV-Seq) enables de novo metagenomic reconstruction of DNA and RNA viral genomes
Unifying genomics and transcriptomics in single cells with ResolveOME™ amplification chemistry to illuminate oncogenic and drug resistance mechanisms
Unravelling genome-wide mosaic microsatellite mutations at single-cell resolution
Validation of the first PGT-whole genome sequencing approach including mitochondrial variants
White Paper: CRISPR/Cas9 Gene Editing
White Paper: iPSC Therapies
White Paper: Viral Gene Therapies
Support
A Fully Integrated Workflow Based on ResolveDNA® WGA for Complete Analysis of Human Embryos for Aneuploidy and Monogenic Disease (PGT-A + M)
Accurate Single-cell Genomic Analysis Holds the Key to Understanding Cancer Heterogeneity
Analysis of Somatic SNV and Indels in Single Neurons using ResolveDNA Whole Genome Amplification
Assessing the Heterogeneity of Single Cancer Cells using Primary Template directed Amplification (PTA)
BaseJumper Cloud End User License Agreement
BaseJumper FAQs
BaseJumper Local End User License Agreement
BaseJumper® Docs
BioSkryb Genomics, Inc. Kick Start Your Research Initiative Terms and Conditions
Contact us for WGA, library preparation, and cell sorting protocols
Genomic Analysis of Single Bacteria using ResolveDNA® Microbiome
Integrated Workflow for Spatial Single Cell Genome Analysis
Pairing Uniform Whole-Genome Amplification with Simple Single-cell Sorting
Resolve Training
ResolveDNA® in primary breast cancer
ResolveDNA® Interactive Tech Note
ResolveDNA® Lysis Optimization
ResolveDNA® Single Cell 384 WES General (TAS-094.1)
ResolveDNA® Single Cell 384 WES Tecan (TAS-091.2)
ResolveDNA® Single Cell 384 WGS General (TAS-070.4)
ResolveDNA® Single Cell 384 WGS Tecan (TAS-087.1)
ResolveDNA® Single Cell 96 WES (TAS-081.1)
ResolveDNA® Single Cell 96 WGS (TAS-068.6)
ResolveDNA® WGA v2 (TAS-097)
ResolveOME™ and ResolveDNA® Data Preprocessing with Fastp Using the Cloud-based BaseJumper® Platform
ResolveOME™ Single Cell 384 WES General (TAS-092.1)
ResolveOME™ Single Cell 384 WES Tecan (TAS-088.2)
ResolveOME™ Single Cell 384 WGS General (TAS-063.1)
ResolveOME™ Single Cell 384 WGS INTEGRA (TAS-071.1)
ResolveOME™ Single Cell 384 WGS Tecan (TAS-086.2)
ResolveOME™ Single Cell 96 WES (TAS-082.1)
ResolveOME™ Single Cell 96 WGS (TAS-074.5)
ResolveOME™: Comprehensive Multi-omic Single-Cell Analysis
Single-cell Isolation and Enrichment
Videos
AACR 2023: A multiomic, single-cell lens on clonal evolution in breast cancer
AACR 2024: Adding Phenotypic Context to the Genomic Foundation with ResolveOME
AMP 2023: Discover Tumor Heterogeneity with Integrated Single-Cell Genomics and Transcriptomics
ASHG: Primary Template-directed Amplification
BaseJumper® Demo
Breast Cancer Multiomics: Unified Insights in Tumor Heterogeneity
Discover the difference BioSkryb Genomics can make for you in WGA
Discover the “Why” behind BioSkryb Genomics
Enabling Rich Understanding of Gene-Edited Cells with Single-Cell Multiomics
Gene Editing: Past, Present, and Future
Get to know BioSkryb first hand
Harnessing Biotechnological Innovation for Pediatric Cancer
Leveraging single-cell whole genome sequencing to identify CRISPR/Cas9 gene editing on- and off-target events
Resolve cancer heterogeneity with single-cell resolution
ResolveOME™
SFAF: Studying Cellular Evolution with Primary Template-directed Amplification (PTA)
Somatic Mosaicism across Human Tissues: single-cell DNA sequencing and the life histories of normal cells
Somatic Mutations in Single-Cell Sequencing: Separating Signal from Noise
Toward Personalized High-Resolution Leukemia Treatments Strategies using Single-Cell Genomics
Tracing the origin of pediatric leukemia using single-cell genome sequencing
Whole Genome Amplification: Studying Tissue Mosaicism and Evolution with Primary Template-Directed Amplification
